Date/Time
Date(s) - 11/30/2020
All Day

Categories

• 2020 Seminar Series
• Dinesh O. Shah Annual Lecture in Surface Science

“UNDERSTANDING AND OVERCOMING BIOLOGICAL BARRIERS FOR DRUG DELIVERY”

Virtual Event
Monday, Nov. 30 at 9:30 a.m.

Register for the event

Abstract:

Effective delivery of drugs is a major problem in today’s healthcare. At a fundamental level, the challenge of drug delivery reflects the fact that the drug distribution in the body is limited by the body’s natural metabolic processes and transport barriers. These biological barriers, while serving an important purpose of regulating the body’s metabolic functions, limit the drug dose that ultimately reaches the target site. Accordingly, many drugs fail to reach their full therapeutic potential. Our research aims at developing a fundamental understanding of the body’s key biological barriers such as skin, intestinal epithelium and the immune system, and utilizing this understanding to develop novel means to negotiate these barriers to deliver drugs. Our research has led to the understanding of how transport properties of biological barriers can be modulated to deliver drugs in effective ways for the treatment of diseases such as diabetes and cancer, among others. I will present an overview of the lessons learned from our exploration of these biological barriers. 

Biography: 

Samir Mitragotri is the Hiller Professor of Bioengineering and Wyss Professor of Biologically Inspired Engineering at Harvard University. His research has provided new insights into biological barriers of skin and gastrointestinal tract, among others. His research has also led to new methods of transdermal, oral, and targeted drug delivery. He is an author of over 300 publications and is a Thomson Reuters Highly Cited Researcher. Prof. Mitragotri is highly active in translating his inventions to clinical and commercial products. He is an inventor on over 180 patents and patent applications. His inventions have led to several products that have been commercialized or are in advanced clinical development. He is an elected member of the National Academy of Engineering, National Academy of Medicine and the National Academy of Inventors. He is a foreign member of the Indian National Academy of Engineering. He is also an elected fellow of AAAS, CRS, BMES, AIMBE, and AAPS. He received a B.S. in Chemical Engineering from the Institute of Chemical Technology, India and a Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology. He is the Editor-in-Chief of AIChE’s and SBE’s journal Bioengineering and Translational Medicine.

Symposium Schedule

9:30 – 9:35 AM EST	Symposium Introduction with Dr. Carlos Rinaldi, Dean’s Leadership Professor and Chair, Department of Chemical Engineering
9:35 – 10:30 AM EST	Seminar: “Understanding and Overcoming Biological Barriers for Drug Delivery” https://ufl.zoom.us/j/95536169747
10:30 – 10:45 AM EST	Break
10:45 – 11:00 AM EST	Symposium Speaker Introductions, Piyush Jain
11:00 – 11:30 AM EST	Speaker 1 Carlos Rinaldi, Dean’s Leadership Professor and Chair, Department of Chemical Engineering Invited Talk: Tracking nanomedicines and cell therapies using magnetic particle imaging
11:30 – 12:00 PM EST	Speaker 2 Ben Keselowsky, Professor of Biomedical Engineering & Associate Chair for Graduate Studies Invited Talk: Tissue-Anchored Enzyme for Suppressive Metabolic Immune Engineering
12:00 – 1:00 PM EST	Lunch Break
1:00 – 1:25 PM EST	Speaker 3 (Pre-Recorded) Elias Sayour, Assistant Professor of Neurosurgery, and Pediatrics Invited Talk: Overcoming challenges to immunotherapy in solid tumors
1:25 – 1:55 PM EST	Speaker 4 Blanka Sharma, Associate Professor of Biomedical Engineering Invited Talk: Engineering Targeted Drug Delivery Systems for Osteoarthritis
1:55 – 2:25 PM EST	Speaker 5 (Lightning Round) Yeongseon Jang, Assistant Professor of Chemical Engineering Invited Talk: Multifunctional, Biomimetic Soft Materials with Controlled Nanostructure and Stiffness Piyush Jain, Assistant Professor of Chemical Engineering Invited Talk: Engineered CRISPR/Cas systems as novel diagnostics
2:25 – 2:40 PM EST	Coffee Break
2:40 – 3:10 PM EST	Speaker 6 Tom Schmittgen, Professor and Chair of the Department of Pharmaceutics Invited Talk: The erythrocyte-enriched miR-451a is enhanced in CNS exosomes following impairment of the blood brain barrier
3:10 – 3:40 PM EST	Speaker 7 Arun Srivastava, George H. Kitzman Professor of Genetics and Chief of Division of Cellular & Molecular Therapy in the Departments of Pediatrics, and Molecular Genetics & Microbiology, and Powell Gene Therapy Center Invited Talk: Gene Therapy of Hemophilia B with AAV Vectors
3:40 – 4:10 PM EST	Speaker 8 (Lightning Round) Whitney Stoppel, Assistant Professor of Chemical Engineering Invited Talk: Engineering Silk Fibroin-Based Materials for Tunable Delivery of Small Molecules and Oxygen Carl Denard, Assistant Professor of Chemical Engineering Invited Talk: Deciphering and Engineering the Substrate Specificity of Protein-Modifying Enzymes
4:10 – 4:15 PM EST	Piyush Jain, Final Remarks and Thank you