Synthesis and Characterization of Magnetic Nanoparticles for Biomedical Applications

September 29, 2019 in Contributions, HomePage Slider

Although magnetic nanoparticles have been synthesized since the 1960’s, most methods to obtain them yield particles with sub-optimal magnetic properties. Furthermore, many formulations intended for use in aqueous-phase result in rapid aggregation and precipitation in biological environments and in cell culture media. These limitations seriously hinder development of new biomedical applications of magnetic nanoparticles, such as nanoscale thermal therapy, magnetic particle imaging, and therapeutic delivery. Our group has made fundamental contributions to the synthesis and characterization of magnetic nanoparticles for biomedical applications by developing methods to synthesize nearly defect free particles with optimal magnetic properties, inexpensive and scalable methods to coat magnetic nanoparticles with covalently grafted layers of polysaccharides and polymers, and reporting rigorous methods of magnetic characterization with an emphasis on applications of these materials in time-varying magnetic fields.

Related Publications:

  • Mythreyi UnniG, Jinling Zhang, Thomas George, Mark Segal, Hugh Fan, and Carlos Rinaldi, “Engineering magnetic nanoparticles and their integration with microfluidics for tumor cell isolation.” Journal of Colloid and Interface Science, 564:204-215, 2020. [https://doi.org/10.1016/j.jcis.2019.12.092]
  • Ishita SinghG, Christopher S. Lacko, Zhiyuan ZhaoG, Christine S. Schmidt, and Carlos Rinaldi, “Preparation and evaluation of microfluidic magnetic alginate microparticles for magnetically templated hydrogels.” Journal of Colloid and Interface Science, 561:647-658, 2020. [https://doi.org/10.1016/j.jcis.2019.11.040]
  • Eric Fuller*G, Georg M. Scheutz*, Angela JimenezU, Parker LewisU, Shehaab SavliwalaG, Sitong LiuG, Brent S. Sumerlin, and Carlos Rinaldi, “Theranostic nanocarriers combining high drug loading and magnetic particle imaging.” International Journal of Pharmaceutics, 572, 118796, 2019. [https://doi.org/10.1016/j.ijpharm.2019.118796]
  • Isaac M. Adjei, Hao Yang, Glendon Plumton, Lorena Maldonado-CamargoG, Jon Dobson, Carlos Rinaldi, Huabei Jiang, and Blanka Sharma, “Multifunctional nanoparticles for intracellular drug delivery and photoacoustic imaging of mesenchymal stem cells.” Drug Delivery and Translational Research, 9(3):652-666,2019. [http://doi.org/10.1007/s13346-019-00621-6]
  • Eric FullerG, Hao Sun, Rohan DhavalikarG, Mythreyi UnniG, Goerg Scheutz, Brent S. Sumerlin, and Carlos Rinaldi, “Externally triggered heat and drug release from magnetically controlled nanocarriers.” ACS Applied Polymer Materials, 1(2):211-220, 2019. [http://doi.org/10.1021/acsapm.8b00100]
  • Melissa Cruz-AcuñaG, Justin Halman, Kyrill A. Afonin, Jon Dobson, and Carlos Rinaldi, “Magnetic nanoparticles loaded with functional RNA nanoparticles.” Nanoscale, 10:17761-17770, 2018. [http://doi.org/10.1039/C8NR04254C]
  • Rui Zhang, Benjamin Fellows, Nikorn Pothayee, Nan Hu, Nipon Pothayee, Ami Jo,Ana C. BohorquezG, Carlos Rinaldi, Alan P. Koretsky, O. Thompson Mefford, Rickey M. Davis and Judy S. Riffle, “Ammonium Bisphosphonate-Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging, with Potential Hyperthermia and Triggered Drug Release.” Journal of Nanomaterials, 2018:4341580, 2018. [http://doi.org/10.1155/2018/4341580]
  • Andrew GarciaG, Chris Lacko, Catherine SnyderU, Ana C. BohorquezG, Christine E. Schmidt, and Carlos Rinaldi, “Preparation of magnetic alginate microspheres with controllable size through emulsification and ionic crosslinking.” Colloids and Surfaces A: Physicochemical and Engineering Aspects, 529:119-127, 2017. [http://doi.org/10.1016/j.colsurfa.2017.05.058]
  • Mythreyi UnniG, Amanda Uhl, Shehaab SavliwalaG, Benjamin Savitzky, Rohan DhavalikarG, Nicolas Garraud, David Arnold, Lena Kourkoutis, Jennifer Andrew, and Carlos Rinaldi, “Thermal decomposition synthesis of iron oxide nanoparticles with diminished magnetic dead layer by controlled addition of oxygen.” ACS Nano, 11(2):2284-2303, 2017. [http://doi.org/10.1021/acsnano.7b00609]
  • Melissa Cruz-AcuñaG, Lorena P. Maldonado-CamargoG, Jon Dobson, and Carlos Rinaldi, “From Oleic Acid-Capped Iron Oxide Nanoparticles to Linked Polyethyleneimine Single-Particle Magnetofectins.” Journal of Nanoparticle Research, 18(9):268 2016. [http://doi.org/10.1007/s11051-016-3577-9]
  • Lorena P. Maldonado-CamargoG, Isaac Torres-DíazP, Maria E. Hernández, and Carlos Rinaldi, “Estimating the contribution of Brownian and Néel relaxation in a magnetic fluid through dynamic magnetic susceptibility measurements.” Journal of Magnetism and Magnetic Materials, 412:223-233,2016. [http://doi.org/10.1016/j.jmmm.2016.03.087]
  • Fernando Mérida, Andreina ChiuG, Ana BohórquezG, Lorena Maldonado, M.-E. Pérez, L. Pericchi, Madeline Torres-Lugo, Carlos Rinaldi, “Optimization of synthesis and peptization steps to obtain iron oxide nanoparticles with high specific absorption rates.” Journal of Magnetism and Magnetic Materials, 394:361-371,2015. [http://doi.org/10.1016/j.jmmm.2015.06.076]
  • Erika C. Vreeland, J. Watt, G.B. Schober, B.G. Hance, M.J. Austin, A.D. Price, B.D. Fellows, T.C. Monson, N.S. Hudak, H. Bao, Lorena Maldonado-CamargoG, Carlos Rinaldi, Dale L. Huber, “Enhanced nanoparticle size control by extending LaMer’s mechanism.” Chemistry of Materials, 27(17):6059-6066,2015. [http://doi.org/10.1021/acs.chemmater.5b02510]
  • Nathalie M. Pinkerton, Marian E. Gindy, Victoria C. Calero-DdelCG, T. Wolfson, D. Adler, D. Gao, S. Lee, M. Zevon, G. Poirier, N. Yao, C. Pacheco, M.T. Therien, Carlos Rinaldi, P.J. Sinko, Robert K. Prud’homme, “Single-Step Assembly of Multi-Modal Imaging and Theranostic Nanocarriers: MRI and Long-Wavelength Fluorescence Imaging,” Advanced Healthcare Materials, 4(9):1376-1385, 2015. [http://doi.org/10.1002/adhm.201400766]
  • Edwin de la Cruz-MontoyaG and Carlos Rinaldi, “Preparation of magnetic polymer colloids with Brownian magnetic relaxation,” Colloid and Polymer Science, 292:1191-1198,2014. [http://doi.org/10.1007/s00396-014-3163-6]
  • G.A. Sotiriou, M.A. Visbal-Onufrak, A. Teleki, Eduardo J. Juan, A.M. Hirt, S.E. Pratsinis, and Carlos Rinaldi, “Thermal energy dissipation by SiO2-coated plasmonic superparamagnetic nanoparticles in alternating magnetic fields.” Chemistry of Materials, 25(22):4603-4612, 2013. [http://doi.org/10.1021/cm402896x]
  • Roberto Olayo-VallesG and Carlos Rinaldi, “Modulation of interparticle interactions and specific absorption rate in magnetomicelles through changes in molecular weight of hydrophobic polymer block.” Particle & Particle System Characterization, 30(11):964-971, 2013. [http://doi.org/10.1002/ppsc.201300157]
  • Vanessa Ayala-RiveraG, Adriana P. HerreraG, Magda Latorre-EstevesP, Madeline Torres-Lugo, and Carlos Rinaldi, “Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran coated iron oxide nanoparticles.” Journal of Nanoparticle Research, 15(8):1874, 2013. [http://doi.org/10.1007/s11051-013-1874-0]
  • Adriana P. HerreraG, Liliana Polo-CorralesG, and Carlos Rinaldi, “Influence of aging time of oleate precursor on the magnetic relaxation of cobalt ferrite nanoparticles synthesized by the thermal decomposition method.” Journal of Magnetism and Magnetic Materials, 328:41-52, 2013. [http://doi.org/10.1016/j.jmmm.2012.09.069]
  • Lenibel Santiago-RodríguezP, M. Montalvo-LafontaineU, C. Castro, J. Méndez-Vega, Magda Latorre-Esteves, Eduardo J. Juan, E. Mora, Madeline Torres-Lugo, and Carlos Rinaldi, “Synthesis, Stability, Cellular Uptake, and Blood Circulation Time of Carboxymethyl-Inulin Coated Magnetic Nanoparticles.” Journal of Materials Chemistry B, 1:2807-2817, 2013. [http://doi.org/10.1039/c3tb20256a]
  • Carola BarreraG, Adriana P. HerreraG, Nayla BezaresU, Esteban Fachini, Juan P. Hinestroza, and Carlos Rinaldi, “Effect of poly(ethylene oxide) graft molecular weight on the colloidal properties of iron oxide nanoparticles for biomedical applications.” Journal of Colloid and Interface Science, 377:40-50, 2012. [http://doi.org/10.1016/j.jcis.2012.03.050]
  • Mar CreixellG, Adriana P. HerreraG, Vanessa AyalaG, Magda Latorre-Esteves, M. Perez-Torres, Madeline Torres-Lugo, and Carlos Rinaldi, “Preparation of EGF conjugated magnetic nanoparticles and their internalization into EGFR overexpressing cancer cells.” Journal of Magnetism and Magnetic Materials, 322(15):2244-2250, 2010. [http://doi.org/10.1016/j.jmmm.2010.02.019]
  • Victoria L. Calero-DdelCG, A.M. González, and Carlos Rinaldi, “A statistical analysis to control the growth of cobalt ferrite nanoparticles synthesized by the thermal decomposition method,” Journal of Manufacturing Science and Engineering, 132(3):030914, 2010. [http://doi.org/10.1115/1.4001717]
  • Victoria L. CaleroG and Carlos Rinaldi, “Effect of sample concentration on the determination of the anisotropy constant of magnetite nanoparticles.” IEEE Transactions on Magnetics, 46(3):852-859, 2010. [http://doi.org/10.1109/TMAG.2009.2032240]
  • Mar CreixellG, Adriana P. HerreraG, Magda Latorre-EstevesP, Vanessa AyalaG, Madeline Torres-Lugo, and Carlos Rinaldi, “The effect of graft method on the stability and cytotoxicity of carboxymethyl dextran coated magnetic nanoparticles.” Journal of Materials Chemistry, 20:8539-8547, 2010. [http://doi.org/10.1039/C0JM01504K]
  • Magda Latorre-EstevesP, Angel D. CortesU, Madeline Torres-Lugo, and Carlos Rinaldi, “Synthesis and characterization of a novel carboxymethyl dextran-coated Mn/Zn ferrite for biomedical applications.” Journal of Magnetism and Magnetic Materials, 321(19): 3061-3066, October 2009. [http://doi.org/10.1016/j.jmmm.2009.05.023]
  • Carola BarreraG, Adriana P. HerreraG, Yashira ZayasU, and Carlos Rinaldi, “Surface modification of monodisperse magnetic nanoparticles for biomedical applications.” Journal of Magnetism and Magnetic Materials, 321:1397-1399, 2009. [http://doi.org/10.1016/j.jmmm.2009.02.046]
  • Alejandro Lopez-CruzU, Carola BarreraG, Victoria L. CaleroG, and Carlos Rinaldi, “Water dispersible iron oxide nanoparticles coated with covalently linked chitosan.” Journal of Materials Chemistry, 19: 6870-6876, 2009. [http://doi.org/10.1039/b0908777j]
  • Carola BarreraG, Adriana P. HerreraG, and Carlos Rinaldi, “Colloidal dispersions of monodisperse magnetite nanoparticles modified with poly(ethylene glycol).” Journal of Colloid and Interface Science, 329:107-113, 2009. [http://doi.org/10.1016/j.jcis.2008.09.071]
  • Adriana P. HerreraG, Carola BarreraG, and Carlos Rinaldi, “Synthesis and functionalization of magnetite nanoparticles with aminopropyl-silane and carboxymethyl-dextran.” Journal of Materials Chemistry, 18: 3650-3654, 2008. [http://doi.org/10.1039/b805256e]
  • Adriana P. HerreraG, María Rodríguez-MoyaU, Madeline Torres-Lugo, and Carlos Rinaldi, “Multifunctional magnetite nanoparticles coated with fluorescent-thermoresponsive polymeric shells.” Journal of Materials Chemistry, 18: 855-858, 2008. [http://doi.org/10.1039/B718210D]
  • Victoria Calero DdelCG and Carlos Rinaldi, “Synthesis and characterization of cobalt substituted ferrite nanoparticles,” Journal of Magnetism and Magnetic Materials, 314:60-67, 2007. [http://doi.org/10.1016/j.jmmm.2006.12.030]